1-(phenylsulfonyl)indole CAS 40899-71-6
Product Name: 1-(phenylsulfonyl)indole
CAS: 40899-71-6
MF: C14H11NO2S
MW: 257.31
EINECS: 642-614-7
Melting point: 78-80 °C
Boiling point: 192°C
Density: 1.26±0.1 g/cm3
Fp: 192°C/3mm
Storage temp.: Sealed in dry,Room Temperature
1. 1-(Phenylsulfonyl)indole CAS 40899-71-6 is widely used as a key intermediate in pharmaceutical development, particularly for drugs targeting neurological disorders, and in the synthesis of antiplasmodial, antifungal, anti-HIV-1, and antibacterial agents.
2. 1-(Phenylsulfonyl)indole serves as a versatile building block in organic synthesis, enabling highly regioselective Friedel-Crafts acylation at the C-3 position with yields of 81-99%.
3. 1-(Phenylsulfonyl)indole is utilized in medicinal chemistry as a privileged pharmacophore for high-affinity 5-HT6 receptor antagonists (Ki = 13 nM) and EphA2 inhibitors (IC50 = 2.6 μM).
Packed in 1 kg/bag, 25 kg/drum
1. 1-(Phenylsulfonyl)indole CAS 40899-71-6 causes skin irritation (H315) and serious eye irritation (H319).
2. 1-(Phenylsulfonyl)indole may cause respiratory irritation (H335); avoid breathing dust and handle in a well-ventilated area.
3. When handling 1-(Phenylsulfonyl)indole, wear protective gloves and eye/face protection. In case of eye contact, rinse cautiously with water for several minutes and seek medical advice if irritation persists.
1. Isolate the spill area of 1-(Phenylsulfonyl)indole, ensure adequate ventilation, and wear full personal protective equipment including gloves, safety goggles, and a dust mask.
2. Avoid generating dust from 1-(Phenylsulfonyl)indole; carefully sweep up or vacuum the spilled material and place it into a sealed, suitable container for disposal.
3. Prevent 1-(Phenylsulfonyl)indole from entering drains or waterways, and dispose of all collected waste in accordance with local environmental regulations.
1. Store 1-(Phenylsulfonyl)indole CAS 40899-71-6 in a tightly sealed container under inert gas (e.g., nitrogen) to protect it from air, and keep it in a cool, dark place below 15°C.
2. For long-term stability, storage at 0-8°C is recommended.
3. Keep 1-(Phenylsulfonyl)indole away from strong oxidizing agents, strong acids, and reducing agents.
