2-Amino-4 6-dichloropyrimidine CAS 56-05-3
Product name:2-Amino-4 6-dichloropyrimidine
CAS:56-05-3
MF:C4H3Cl2N3
MW:163.99
Density:1.6662 g/cm3
Melting point:219-222 °C
Boiling point:220-223°C
1. 2-Amino-4,6-dichloropyrimidine is primarily used as a key intermediate in the synthesis of pharmaceuticals and agrochemicals, serving as a building block for creating various biologically active pyrimidine derivatives.
2. 2-Amino-4,6-dichloropyrimidine is utilized in medicinal chemistry research to synthesize antitumor agents, antibacterial compounds, anti-inflammatory agents, and antifilarial drugs with enzyme-inhibiting properties.
3. 2-Amino-4,6-dichloropyrimidine is employed in the preparation of pyrazolo pyrimidines via microwave-assisted synthesis and in the synthesis of anti-HIV carbocyclic purine nucleosides.
Packed in 1kg/bag, 25kg/drum
1. 2-Amino-4,6-dichloropyrimidine is a synthetic organic compound produced via chlorination of 2-amino-4,6-dihydroxypyrimidine using phosphorus oxychloride (POCl₃) at temperatures of 50-100°C in the presence of a solvent and an acid removing agent.
2. 2-Amino-4,6-dichloropyrimidine is commercially manufactured with CAS Registry Number 56-05-3, molecular formula C₄H₃Cl₂N₃, and molecular weight 163.99 g/mol, available in purities ≥95-98% from chemical suppliers.
3. An improved industrial process for 2-Amino-4,6-dichloropyrimidine involves hydrolyzing the by-product 4,6-dichloro-2-pyrimidinylphosphoramidic dichloride to further increase the yield of the desired product.
1. If inhaled, move the person exposed to 2-Amino-4,6-dichloropyrimidine to fresh air, keep at rest in a position comfortable for breathing, and call a POISON CENTER or doctor if feeling unwell.
2. If in eyes, rinse 2-Amino-4,6-dichloropyrimidine cautiously with plenty of water for at least 15 minutes, remove contact lenses if present and easy to do, and get medical attention if eye irritation persists.
3. If on skin, wash 2-Amino-4,6-dichloropyrimidine with plenty of soap and water, take off contaminated clothing and wash before reuse, and get medical advice if skin irritation occurs.
1. Store 2-Amino-4,6-dichloropyrimidine in a tightly closed container in a cool, dry, well-ventilated place, with the container kept tightly sealed.
2. For long-term storage of 2-Amino-4,6-dichloropyrimidine powder, store at room temperature in a dry location; stock solutions can be stored at -20°C for up to 1 month or at -80°C for up to 6 months, avoiding repeated freeze-thaw cycles.
3. Store 2-Amino-4,6-dichloropyrimidine locked up (P405), away from incompatible materials, and dispose of contents/container to an approved waste disposal plant.
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