2-Hydroxypropyl-γ-cyclodextrin CAS 128446-34-4
Product Name: 2-Hydroxypropyl-γ-cyclodextrin
CAS: 128446-34-4
MF: C48H80-nO40.(C3H7O)n
MW: 0
EINECS: 207-166-5
Melting point: 52-55 °C
Boiling point: 97-98 °C3 mm Hg
1. 2-Hydroxypropyl-γ-cyclodextrin is primarily used as a pharmaceutical solubilizing agent to enhance the water solubility, stability, and bioavailability of poorly soluble drugs in parenteral and oral formulations .
2. 2-Hydroxypropyl-γ-cyclodextrin is used in supramolecular chemistry and cell culture applications to solubilize macromolecules such as cholesterol and to modulate lysosomal dynamics .
3. 2-Hydroxypropyl-γ-cyclodextrin is used as a chiral selector and mobile phase additive in analytical techniques like HPLC and micellar electrokinetic chromatography (MEKC) .
Packed in 1kg/bag or 20kg/drum.
1. 2-Hydroxypropyl-γ-cyclodextrin is a synthetic, chemically modified cyclic oligosaccharide derived from natural γ-cyclodextrin, which itself is produced from starch .
2. 2-Hydroxypropyl-γ-cyclodextrin is synthesized by reacting γ-cyclodextrin with propylene oxide under alkaline conditions, introducing 2-hydroxypropyl groups to improve water solubility .
3. 2-Hydroxypropyl-γ-cyclodextrin can be produced via solution-based synthesis or greener mechanochemical methods such as high-energy ball milling .
1. 2-Hydroxypropyl-γ-cyclodextrin is classified as a combustible solid and has a WGK 3 water hazard classification .
2. Preclinical studies indicate 2-Hydroxypropyl-γ-cyclodextrin is less toxic than HP-β-CD, but high doses caused proteinuria and body weight loss in Alport mice .
3. For research use only, 2-Hydroxypropyl-γ-cyclodextrin is not intended for diagnostic or therapeutic use in humans without regulatory approval .
1. Store 2-Hydroxypropyl-γ-cyclodextrin at room temperature for short-term use, but long-term storage of 2-Hydroxypropyl-γ-cyclodextrin is recommended at 4°C (refrigerated) .
2. Store 2-Hydroxypropyl-γ-cyclodextrin in a tightly closed container in a cool, dry place away from incompatible materials .
3. Under recommended storage conditions, 2-Hydroxypropyl-γ-cyclodextrin is stable for at least 6 months after receipt .
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