4-Phenylbutyric acid CAS 1821-12-1
Product Name: 4-Phenylbutyric acid
CAS: 1821-12-1
MF: C10H12O2
MW: 164.2
EINECS: 217-341-8
Density: 1.0326 g/cm3
Melting point: 49-51 °C
Boiling point: 165 °C
1. 4-Phenylbutyric acid is used as a pharmaceutical ingredient, specifically as the active moiety in the drug sodium phenylbutyrate (BUPHENYL), for the chronic management of urea cycle disorders .
2. 4-Phenylbutyric acid is studied as a research tool for its role as a histone deacetylase (HDAC) inhibitor and a chemical chaperone to regulate protein folding and lipid homeostasis .
3. 4-Phenylbutyric acid serves as a chemical intermediate in organic synthesis and is utilized as a building block for producing pharmaceuticals and fine chemicals .
Packed in 1kg/bag, 25kg/drum, 200kg/drum.
1. 4-Phenylbutyric acid is a synthetic organic compound produced via the Friedel-Crafts reaction of benzene with butyrolactone in the presence of a Lewis acid catalyst such as aluminum chloride, followed by neutralization with base .
2. 4-Phenylbutyric acid is derived chemically from butyric acid, with a phenyl group substituted at the C-4 position of the butyric acid chain .
3. 4-Phenylbutyric acid is commercially manufactured as a white to off-white crystalline solid with purity >98-99% and is available from chemical suppliers for pharmaceutical and research use .
1. 4-Phenylbutyric acid is classified with GHS Warning, with hazard statements H315 (causes skin irritation) and H319 (causes serious eye irritation) .
2. When handling 4-Phenylbutyric acid, wear protective gloves, eye protection, and face protection, and wash skin thoroughly after handling .
3. For the prescription drug sodium phenylbutyrate, side effects include menstrual irregularities, body odor, bad taste, and metabolic acidosis, requiring regular blood monitoring under physician supervision .
1. Store 4-Phenylbutyric acid at room temperature in a cool and dark place, with recommended storage below 15°C (59°F) .
2. Store 4-Phenylbutyric acid long-term in a cool, dry area with the container tightly closed, as 4-Phenylbutyric acid is a solid at room temperature with a melting point of 49-52°C .
3. For the pharmaceutical sodium phenylbutyrate powder, store at controlled room temperature and keep the container tightly closed .
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