7-chloro-1H-indole-2-carboxylic acid CAS 28899-75-4
Product Name: 7-chloro-1H-indole-2-carboxylic acid
CAS: 28899-75-4
MF: C9H6ClNO2
MW: 195.6
EINECS: 249-296-5
Boiling point: 449.7±25.0 °C
Density: 1.548±0.06 g/cm3
Storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
1. 7-Chloro-1H-indole-2-carboxylic acid CAS 28899-75-4 serves as a key structural scaffold in medicinal chemistry, particularly for developing modulators of the NMDA receptor glycine site, where it mimics the carboxylate and hydrogen-bonding interactions of glycine .
2. 7-Chloro-1H-indole-2-carboxylic acid is employed as a versatile building block in organic synthesis for constructing complex alkaloids such as dibromophakellin and trachelanthamidine .
3. 7-Chloro-1H-indole-2-carboxylic acid has been identified as a hit compound in structure-based screening campaigns for inhibitors of hepatitis C virus NS3 protease and human mitogen-activated protein kinase kinase 4 (MAP2K4), showing an IC50 of 281 nM against the latter .
Packed in 1 kg/bag, 25 kg/drum
1. 7-Chloro-1H-indole-2-carboxylic acid is harmful if swallowed and causes skin, eye, and respiratory tract irritation .
2. When handling 7-Chloro-1H-indole-2-carboxylic acid, wear full personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing, and work in a fume hood .
3. In case of eye contact with 7-Chloro-1H-indole-2-carboxylic acid, rinse cautiously with water for several minutes, remove contact lenses if present, and seek medical attention if irritation persists .
1. Isolate the spill area of 7-Chloro-1H-indole-2-carboxylic acid CAS 28899-75-4, ensure adequate ventilation, and wear full personal protective equipment including gloves, safety goggles, and a dust mask .
2. Avoid generating dust from 7-Chloro-1H-indole-2-carboxylic acid; carefully sweep up or vacuum the spilled material and place it into a sealed, suitable container for disposal .
3. Prevent 7-Chloro-1H-indole-2-carboxylic acid from entering drains or waterways, and dispose of all collected waste in accordance with local environmental regulations .
1. Store 7-Chloro-1H-indole-2-carboxylic acid CAS 28899-75-4 in a tightly sealed container under inert gas at a refrigerated temperature of 2-8°C .
2. Long-term storage of 7-Chloro-1H-indole-2-carboxylic acid is recommended at -20°C to ensure stability .
3. Protect 7-Chloro-1H-indole-2-carboxylic acid from light and keep it away from strong oxidizing agents .
