Azidotrimethyisilane / TMSA CAS 4648-54-8
Product Name: Azidotrimethylsilane
CAS: 4648-54-8
MF: C3H9N3Si
MW: 115.21
EINECS: 225-078-5
Density: 0.876 g/mL
Melting point: -95°C
Boiling point: 92-95 °C
Refractive index: n20/D 1.415
Fp: 74 °F
Storage temp.: 2-8°C
1. Azidotrimethylsilane serves as a convenient and versatile azide source in organic synthesis, commonly used for converting alkyl halides or alcohols into azides, and for diazo transfer reactions.
2. Azidotrimethylsilane participates in [3+2] cycloaddition reactions (click chemistry) with alkynes and nitriles to form triazoles and tetrazoles, making it valuable in drug discovery and materials science.
3. Azidotrimethylsilane is used as a silylating agent to protect hydroxyl groups (e.g., in alcohols and phenols) and has applications in bioconjugation and polymer modification.
Packed in 1kg/bag, 25kg/drum
1. Azidotrimethylsilane is highly flammable and toxic if swallowed, in contact with skin, or if inhaled . It is also suspected of causing genetic defects (H341) .
2. Contact with water or moisture liberates toxic gas (hydrogen azide or other nitrogen oxides), and thermal decomposition can produce toxic fumes including nitrogen oxides and carbon monoxide .
3. Wear full protective equipment including chemical-resistant gloves, protective clothing, safety goggles, and face shield. Ensure adequate ventilation and use only under a chemical fume hood .
1. Immediately eliminate all ignition sources, isolate the spill area, and ensure adequate ventilation. Wear full protective equipment and self-contained breathing apparatus if necessary.
2. Contain the spill using an inert, non-combustible absorbent material (e.g., sand) and carefully collect it into a suitable, sealed container for disposal. Do not use water.
3. Prevent the material from entering drains, sewers, or waterways. Dispose of all collected waste in accordance with local environmental regulations.
1. Store Azidotrimethylsilane in a tightly sealed container under an inert atmosphere (e.g., nitrogen or argon) in a refrigerator (typically 0–10°C) , as it is moisture-sensitive and decomposes on contact with water.
2. Keep Azidotrimethylsilane away from strong oxidizing agents, acids, heat, sparks, and open flames because it is highly flammable and reacts with water to release toxic gases.
3. Use non-sparking tools and explosion-proof equipment when handling Azidotrimethylsilane to prevent static discharge ignition.
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