Ethyl 4 4 4-trifluoroacetoacetate CAS 372-31-6
Product Name: Ethyl 4 4 4-trifluoroacetoacetate
CAS: 372-31-6
MF: C6H7F3O3
MW: 184.11
EINECS: 206-750-7
Density: 1.259 g/mL
Melting point: -39 °C
Boiling point: 129-130 °C
1. Ethyl 4,4,4-trifluoroacetoacetate is primarily used as a building block in organic synthesis to construct enantiopure trifluoromethyl-functionalized products, including α-trifluoromethyl-aspartic acid and β-amino acid derivatives .
2. Ethyl 4,4,4-trifluoroacetoacetate is utilized as a key intermediate in the production of fluorinated pharmaceuticals, such as antithyroid agents, and agrochemicals .
3. Ethyl 4,4,4-trifluoroacetoacetate serves as a reagent to introduce the trifluoromethyl group into target molecules, significantly altering their stability, reactivity, and bioavailability .
Packed in 1kg/bottle, 25kg/drum, 200kg/drum.
1. Ethyl 4,4,4-trifluoroacetoacetate is a synthetic organic compound produced via the Claisen condensation reaction between ethyl trifluoroacetate and ethyl acetate in the presence of a base catalyst such as sodium ethoxide .
2. Ethyl 4,4,4-trifluoroacetoacetate is commercially manufactured with CAS Registry Number 372-31-6, molecular formula C6H7F3O3, and is available in purities of 98% or higher from chemical suppliers .
3. Ethyl 4,4,4-trifluoroacetoacetate has also been used in synthetic routes as a reactant for producing various heterocyclic compounds and fluorinated derivatives in medicinal chemistry research .
1. If inhaled, move the person exposed to Ethyl 4,4,4-trifluoroacetoacetate to fresh air and consult a physician if breathing difficulty or irritation develops.
2. If in eyes, rinse Ethyl 4,4,4-trifluoroacetoacetate cautiously with water for several minutes, remove contact lenses if present, and get medical attention if irritation persists.
3. If swallowed, rinse mouth with water, do NOT induce vomiting, and call a poison center or physician immediately .
1. Ethyl 4,4,4-trifluoroacetoacetate is a synthetic organic compound produced via the Claisen condensation reaction between ethyl trifluoroacetate and ethyl acetate in the presence of a base catalyst such as sodium ethoxide .
2. Ethyl 4,4,4-trifluoroacetoacetate is commercially manufactured with CAS Registry Number 372-31-6, molecular formula C6H7F3O3, and is available in purities of 98% or higher from chemical suppliers .
3. Ethyl 4,4,4-trifluoroacetoacetate has also been used in synthetic routes as a reactant for producing various heterocyclic compounds and fluorinated derivatives in medicinal chemistry research .
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