Methyl indole-6-carboxylate CAS 50820-65-0
Product Name: Methyl indole-6-carboxylate
CAS: 50820-65-0
MF: C10H9NO2
MW: 175.18
EINECS: 610-576-0
Melting point: 76-80 °C
Boiling point: 331.7±15.0 °C
Density: 1.253±0.06 g/cm3
Storage temp.: Keep in dark place,Sealed in dry,Room Temperature
1. Methyl indole-6-carboxylate is a key intermediate for synthesizing receptor tyrosine kinase inhibitors (EGFR/VEGFR-2) and hydrazine-1-carbothioamide/oxadiazole libraries with sub-10 μM IC50 values against cancer cell lines.
2. Methyl indole-6-carboxylate serves as a foundational scaffold for N1-benzylation yielding URAT1 inhibitor intermediates (methyl 1-benzyl-1H-indole-6-carboxylate) without requiring protecting group manipulation.
3. Methyl indole-6-carboxylate is used as a reactant for preparing tryptophan dioxygenase inhibitors, ITK inhibitors, antibacterial agents, CB2 cannabinoid receptor ligands, and HCV NS5B polymerase inhibitors.
Packed in 1kg/bag, 25kg/drum
1. Methyl indole-6-carboxylate causes skin irritation, serious eye irritation, and may cause respiratory irritation.
2. When handling Methyl indole-6-carboxylate, wear protective gloves and eye/face protection, and avoid breathing dust.
3. In case of eye contact, rinse cautiously with water for several minutes and remove contact lenses if present; if irritation persists, seek medical advice.
1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment (gloves, safety goggles, dust mask).
2. Avoid generating dust. Carefully sweep or vacuum the spilled material and place it into a sealed, suitable container for disposal.
3. Prevent Methyl indole-6-carboxylate from entering drains or waterways, and dispose of all collected waste in accordance with local environmental regulations.
1. Store Methyl indole-6-carboxylate as a powder at -20°C (stable for up to 3 years) or at 4°C (stable for up to 2 years); store solutions at -80°C for up to 6 months.
2. Keep Methyl indole-6-carboxylate in a tightly sealed container in a cool, dark place (recommended <15°C), under inert gas (e.g., nitrogen), as it is air-sensitive.
3. Keep Methyl indole-6-carboxylate away from strong oxidizing agents, and ensure the storage area is well-ventilated.
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