Methyl4-chloro-1H-indole-3-carboxylate CAS 101909-42-6
Product Name: Methyl4-chloro-1H-indole-3-carboxylate
CAS: 101909-42-6
MF: C10H8ClNO2
MW: 209.63
Melting point: 134-136 °C
Boiling point: 365.5±22.0 °C
Density: 1.381±0.06 g/cm3
Storage temp.: 2-8°C
1. Methyl 4-chloro-1H-indole-3-carboxylate CAS 101909-42-6 is a key synthetic building block for developing CysLT1 receptor antagonists in asthma and inflammation research, with an IC50 of 0.067 μM.
2. The 4-chloro substituent on the indole ring gives Methyl 4-chloro-1H-indole-3-carboxylate a distinct selectivity profile (approximately 537-fold for CysLT1 over CysLT2) that differs from other chloro-regioisomers like the 5- or 7-chloro analogs.
3. Methyl 4-chloro-1H-indole-3-carboxylate serves as a versatile scaffold for synthesizing biologically active molecules with potential anticancer, antimicrobial, and kinase inhibitory activities.
Packed in 1 kg/bag, 25 kg/drum
1. Methyl 4-chloro-1H-indole-3-carboxylate is harmful if swallowed (H302) and causes skin irritation (H315).
2. Methyl 4-chloro-1H-indole-3-carboxylate causes serious eye irritation (H319) and may cause respiratory irritation (H335).
3. When handling Methyl 4-chloro-1H-indole-3-carboxylate, wear protective gloves, eye/face protection, and work in a well-ventilated area. In case of eye contact, rinse cautiously with water for several minutes and seek medical advice if irritation persists.
1. Isolate the spill area of Methyl 4-chloro-1H-indole-3-carboxylate, ensure adequate ventilation, and wear full personal protective equipment including gloves, safety goggles, and a dust mask.
2. Avoid generating dust from Methyl 4-chloro-1H-indole-3-carboxylate; carefully sweep up or vacuum the spilled material and place it into a sealed, suitable container for disposal.
3. Prevent Methyl 4-chloro-1H-indole-3-carboxylate from entering drains or waterways, and dispose of all collected waste in accordance with local environmental regulations.
1. Store Methyl 4-chloro-1H-indole-3-carboxylate in a tightly sealed container in a cool, dry place at 2–8°C to ensure stability and prevent degradation.
2. Protect Methyl 4-chloro-1H-indole-3-carboxylate from moisture and light to maintain chemical integrity.
3. Keep Methyl 4-chloro-1H-indole-3-carboxylate away from strong oxidizing agents.
