Monomethyl fumarate CAS 2756-87-8
Product Name: Monomethyl fumarate
CAS: 2756-87-8
MF: C5H6O4
MW: 130.1
EINECS: 220-412-6
Density: 1.37 g/cm3
Melting point: 144-145 °C
Boiling point: 250.0±23.0 °C
1. Monomethyl fumarate is used to treat adults with relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting MS, and active secondary progressive disease .
2. Monomethyl fumarate is an active metabolite of dimethyl fumarate, and monomethyl fumarate functions as an immunomodulator and antioxidant by inducing the NFE2L2 (Nrf2) transcription factor .
3. Monomethyl fumarate is also used as a research chemical for synthesizing Jumonji C domain-containing histone demethylase inhibitors and other pharmaceutical compounds .
Packed in 25kg/bag.
1. Monomethyl fumarate is a dicarboxylic acid monoester resulting from the formal condensation of one of the carboxy groups of fumaric acid with methanol .
2. Monomethyl fumarate occurs naturally as a metabolite of dimethyl fumarate in the human body after dimethyl fumarate is ingested and metabolized .
3. Monomethyl fumarate is also synthetically manufactured for pharmaceutical and research use .
1. Monomethyl fumarate is classified as an eye irritant and requires handling with protective gloves, safety goggles, and an N95 dust mask during laboratory use .
2. Common side effects of monomethyl fumarate include flushing and gastrointestinal issues such as nausea and diarrhea; taking non-enteric coated aspirin 30 minutes before monomethyl fumarate may reduce flushing .
3. Monomethyl fumarate has WGK 3 water hazard classification and should not be released into the environment .
1. Store unopened bottles of monomethyl fumarate delayed-release capsules in the refrigerator; after opening, store monomethyl fumarate at room temperature away from heat, light, and moisture .
2. Do not store monomethyl fumarate in the bathroom, and discard any unused monomethyl fumarate capsules 3 months after opening the bottle .
3. For laboratory storage of monomethyl fumarate powder, store monomethyl fumarate dry, dark, and at -20°C for up to 1 year, with stock solutions stored at 0-4°C for up to 1 month .
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