Piroxicam-beta-cyclodextrin CAS 96684-39-8
Product Name: piroxicam-beta-cyclodextrin
CAS: 96684-39-8
MF: C57H83N3O39S
MW: 1466.33
EINECS: 1312995-182-4
1. Piroxicam-beta-cyclodextrin is used for the treatment of rheumatic diseases, osteoarthritis, and various acute pain conditions including postoperative pain, dental pain, and musculoskeletal disorders.
2. Piroxicam-beta-cyclodextrin provides anti-inflammatory, analgesic, and antipyretic effects as a nonsteroidal anti-inflammatory drug (NSAID) formulation.
3. Piroxicam-beta-cyclodextrin is clinically indicated when rapid analgesia is required, particularly in acute pain states such as post-extraction dental pain.
Packed in 15kg/carton or 20kg/drum.
1. Piroxicam-beta-cyclodextrin is a synthetic inclusion complex formed by encapsulating the NSAID piroxicam within beta-cyclodextrin, a cyclic oligosaccharide derived from starch.
2. The complexation with beta-cyclodextrin is achieved through supramolecular encapsulation that enhances the aqueous solubility of piroxicam.
3. Piroxicam-beta-cyclodextrin is produced by the pharmaceutical industry as an oral tablet or granule formulation.
1. Piroxicam-beta-cyclodextrin is contraindicated in patients with active peptic ulceration and should be used cautiously in patients with a history of upper gastrointestinal tract disease.
2. Most common adverse events with Piroxicam-beta-cyclodextrin are gastrointestinal in origin, including epigastric pain, heartburn, and nausea, with severe reactions like gastrointestinal bleeding seen in approximately 0.2% of patients.
3. Higher dosages of Piroxicam-beta-cyclodextrin (30-40 mg/day) may be associated with a greater incidence of gastrointestinal adverse effects.
1. Store Piroxicam-beta-cyclodextrin as tablets or granules in a cool, dry place at room temperature.
2. Keep Piroxicam-beta-cyclodextrin in the original container tightly closed and away from moisture.
3. For long-term storage of Piroxicam-beta-cyclodextrin, store in a cool, dry place with stability maintained under recommended conditions.
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